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COVID-19 Vaccine Allocation: Modeling Health Outcomes and Equity Implications of Alternative Strategies Article

Maddalena Ferranna, Daniel Cadarette, David E. Bloom

Engineering 2021, Volume 7, Issue 7,   Pages 924-935 doi: 10.1016/j.eng.2021.03.014

Abstract: This paper evaluates COVID-19 vaccine prioritization strategies proposed to date, focusing on their statedlargest reduction in deaths is achieved by prioritizing older adults in most scenarios, even if the vaccineAdditionally, we investigate the strength of the equity motive that would support an allocation strategyattaching absolute priority to essential workers for a vaccine that reduces infectionfatality risk.

Keywords： Vaccine allocation     COVID-19     Equity     SEIR model    

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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: we outline representative vaccines in multiple routes, while the merits and plights of the existing vaccine

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)-stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants.

Keywords： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: After subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAnother group was treated with the vaccine after tumor implantation.It was found that human SART3 DNA vaccine can elicit a specific CTL reaction from the mouse splenocytesThe vaccine also shows activity in tumor treatment.We conclude that the human SART3 DNA vaccine can induce antitumor ability against tumor cells expressing

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: the urgent needs of coronavirus disease 2019 (COVID-19) epidemic prevention and control, nucleic acid vaccinehas attracted great attention in the vaccine research and development (R&D) field owing to its highParticularly, the R&D process of messenger RNA (mRNA) vaccine has significantly accelerated, andthe mRNA vaccine was approved for the first time to be marketed and used in humans.Subsequently, it analyzes the impact of COVID-19 outbreak on the mRNA vaccine research, summarizes the

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messengerRNA (mRNA) vaccine     coronavirus disease 2019 (COVID-19)     cancer    

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: However, vaccine development has remained challenging.in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccineOur review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and

Keywords： HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

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Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Frontiers of Medicine   Pages 867-877 doi: 10.1007/s11684-023-0995-9

Abstract: The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with

Keywords： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

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Achieving air pollutant emission reduction targets with minimum abatement costs: An enterprise-level allocation

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1459-6

Abstract:

• Quantification of efficiency and fairness of abatement allocation

Keywords： Pollutant emission reduction allocation     Emission reduction measures     Total abatement cost     Economic    

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Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract: and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccineA total of 15 young mice aged 3 weeks to 5 weeks were immunized with the conjugate vaccine, and another15 young mice of the same age were immunized with the licensed Hib-tetanus toxoid (TT) vaccine.This new Hib-PsaA conjugate vaccine can induce both anti-PsaA and anti-Hib immune responses in young

Keywords： conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

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Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China Review

Zhiming Huang, Zhihao Fu, Junzhi Wang

Engineering 2022, Volume 10, Issue 3,   Pages 127-132 doi: 10.1016/j.eng.2022.01.001

Abstract: This review summarizes the overall state of the vaccine industry, research and development (R&D)Ultimately, this review provides a reference for the formulation of a vaccine development strategy inresponse to the current pandemic and the field of vaccine development in the post-pandemic era, as well

Keywords： Regulatory science     COVID-19 vaccine     Vaccine industry    

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The Integration Model of Closed-Loop Supply Chain Resource Allocation Considering Remanufacturing

Xiao-qiu Shi,Yan-yan Li,Wei Long

Frontiers of Engineering Management 2016, Volume 3, Issue 2,   Pages 132-135 doi: 10.15302/J-FEM-2016026

Abstract: integration model of materials requirement planning and distribution resource planning which is a resource allocationIt is a technology of satisfying both production material supply and resource allocation optimizationof reverse logistics of remanufacturing supply chain, we propose a closed-loop supply chain resource allocationWe focus on integration resource allocation model of materials requirement planning and distribution

Keywords： remanufacturing     supply chain     reverse logistics     resource allocation     integration model    

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virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract: Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanif superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract:

Chronic hepatitis B is a major health burden worldwide. In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B. On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeutic vaccines, which have undergone clinical trials. The advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.

Keywords： chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

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Benefit-based cost allocation for residentially distributed photovoltaic systems in China: A cooperative

Xi LUO, Xiaojun LIU, Yanfeng LIU, Jiaping LIU, Yaxing WANG

Frontiers of Engineering Management 2021, Volume 8, Issue 2,   Pages 271-283 doi: 10.1007/s42524-019-0083-7

Abstract: Distributed photovoltaic (PV) systems have constantly been the key to achieve a low-carbon economy in China. However, the development of Chinese distributed PV systems has failed to meet expectations because of their irrational profit and cost allocations. In this study, the methodology for calculating the levelized cost of energy (LCOE) for PV is thoroughly discussed to address this issue. A mixed-integer linear programming model is built to determine the optimal system operation strategy with a benefit analysis. An externality-corrected mathematical model based on Shapley value is established to allocate the cost of distributed PV systems in 15 Chinese cities between the government, utility grid and residents. Results show that (i) an inverse relationship exists between the LCOEs and solar radiation levels; (ii) the government and residents gain extra benefits from the utility grid through net metering policies, and the utility grid should be the highly subsidized participant; (iii) the percentage of cost assigned to the utility grid and government should increase with the expansion of battery bank to weaken the impact of demand response on increasing theoretical subsidies; and (iv) apart from the LCOE, the local residential electricity prices remarkably impact the subsidy calculation results.

Keywords： solar photovoltaic     cost allocation     cooperative game theory     Shapley value     mixed-integer linear programming    

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A holistic approach for evaluating ecological water allocation in the Yellow River Basin of China

YANG Zhifeng, CUI Baoshan, CHEN He

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 99-106 doi: 10.1007/s11783-007-0019-z

Abstract: The characteristics and sustainable management of water resources on a basin scale require that they should be managed using a holistic approach. In this study, a holistic methodology called the holistic approach in a basin scale (HABS) is proposed to determine the ecological water requirements of a whole basin. There are three principles in HABS. First, ecological water requirements in a basin scale indicate not only the coupling of hydrological and ecological systems, but also the exchange of matter and energy between each ecological type through all kinds of physical geography processes. Second, ecological water requirements can be divided into different types according to their functions, and water requirements of different types are compatible. Third, ecological water requirements are related to a multiple system including water quality, water quantity, and time and space, which interact with each other. The holistic approach in a basin scale was then used in the Yellow River Basin and it suggested that 265.0 × 10 m of water, 45% of the total surface water resources, should be allocated to ecological systems, such as rivers, lakes, wetlands and cities, to sustain its function and health. The ecological water requirements of inside river systems and outside river systems were respectively 261.0 × 10 and 3.65 × 10 m.
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Title Author Date Type Operation

COVID-19 Vaccine Allocation: Modeling Health Outcomes and Equity Implications of Alternative Strategies

Maddalena Ferranna, Daniel Cadarette, David E. Bloom

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Journal Article

Achieving air pollutant emission reduction targets with minimum abatement costs: An enterprise-level allocation

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China

Zhiming Huang, Zhihao Fu, Junzhi Wang

Journal Article

The Integration Model of Closed-Loop Supply Chain Resource Allocation Considering Remanufacturing

Xiao-qiu Shi,Yan-yan Li,Wei Long

Journal Article

virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

Benefit-based cost allocation for residentially distributed photovoltaic systems in China: A cooperative

Xi LUO, Xiaojun LIU, Yanfeng LIU, Jiaping LIU, Yaxing WANG

Journal Article

A holistic approach for evaluating ecological water allocation in the Yellow River Basin of China

YANG Zhifeng, CUI Baoshan, CHEN He

Journal Article